Modifying action of metformin on the cytogenetic effects of doxorubicin and cyclophosphamide in mice

BACKGROUND: The causal relationship between mutagenesis and carcinogenesis is well known. Hence the wide interest in study of mutagen-modifying effects natural synthetic compounds. Particular attention drawn to widespread One them, metformin, widely used as a hypoglycemic drug.
 AIM: evaluation influence metformin on cytogenetic doxorubicin cyclophosphamide mouse bone marrow cells.
 MATERIALS AND METHODS: Male F1 CBAxC57Bl/6 hybrid mice were used. Cyclophosphamide (20 mg/kg) or (10 was administered intraperitoneally, given orally once for 4 consecutive days. latter administration combined with mutagen administration. Cytogenetic preparations cells prepared 18 hours after 24 its mutagens. Chromosomal aberrations analyzed according accepted protocols.
 RESULTS: Metformin per se showed no activity at doses 500, 1000, 2000 mg/kg. At dose 500 mg/kg, but not 100 250 reduced doxorubicin. days 100, 250, mg/kg 10 20 increased number metaphases chromosome induced by factor 2 3. 2.5 5 had modifying effect effect.
 CONCLUSION: attenuates enhances cells. This allows us conclude that has properties.